Matthew DeNunzio, MD

Dr. Matthew DeNunzio is a board-certified Internal Medicine Specialist with more than 15 years of experience dedicated to delivering compassionate, patient-centered care. Born and raised in Miami, Florida, Dr. DeNunzio earned his bachelor’s degree in biology from Florida International University before receiving his Doctor of Medicine degree with high honors from Ross University School of Medicine. He completed his residency training at Florida State University, where he developed extensive expertise in preventive medicine, chronic disease management, and acute hospital care. His dedication to fostering strong physician-patient relationships remains the foundation of his approach to healthcare.

Since joining WVL Synergy
in Naples, Florida, Dr. DeNunzio has focused on concierge medicine, emphasizing proactive, preventative healthcare with personalized attention and comprehensive care coordination. Prior to this role, he spent nearly eight years at Naples Community Hospital, where he advanced from hospitalist physician to Medical Director of the North Naples Hospitalist Group, Vice Chair of Internal Medicine, and Chief Medical Informatics Officer (CMIO). In his CMIO role, he successfully led the large-scale implementation of Epic MyChart, helping modernize patient care and communication systems across the organization. His leadership and commitment to innovation have made him a respected figure within the Southwest Florida medical community.

Outside of medicine, Dr. DeNunzio values time with his wife and daughter and embraces activities that promote a healthy work-life balance. He enjoys traveling, exploring different cultures, playing guitar, boating, and fishing. Passionate about giving back, he is an active member of local medical organizations, including CCMS and PPA, and proudly supports the American Heart Association through sponsorships and community initiatives. Through his concierge practice, Dr. DeNunzio is committed to practicing medicine the way it was meant to be—by dedicating meaningful time and attention to each patient while building lasting connections within the community.

• Medical Education Ross University School of Medicine 2012
• Internship(s) Ross University School of Medicine Clinical Clerkshops 2012
• Residency(s) Florida State University Tallahassee Memorial Healthcare 2016

• Board Certified in Internal Medicine

• Graduated with High Honors from Ross University
• Medical Director
• Naples Community Hospital North Campus
• Vice Chair of Internal Medicine
• Naples Community Hospital
• Chief Medical Informatics Officer (CMIO)
• Associate Professor
• University of Central Florida
• Selected as Top Internal Medicine Specialist
• America's Best in Medicine 2026

• CCMS (Collier County Medical Society)
• PPA (concierge medicine group)
• American Heart Association (sponsor and supporter)

• American Heart Association - Event Sponsorship and Race Sponsorship
• Volunteer Firefighter (10 years prior to medical career)

Dr. DeNunzio has one publication from his residency training period. While he notes it as a single publication, it represents his contribution to medical research during his academic training at Florida State University.